PhD Studentship at the University of Glasgow

PhD Studentship at the University of Glasgow:
Causes and Consequences of Individual Variation in Aerobic Scope and
its Association with Immune Response

Supervisory Team: Shaun Killen, Jan Lindström (both of the Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow), Michael Stear (Institute of Infection, Immunity and Inflammation, University of Glasgow)

Background and Motivation: The immune response is enormously important for defending animals against infection but the physiological costs of this response remain largely unknown. While there is some evidence that mounting an immune response increases energy expenditure, the extent of these costs and the underlying mechanisms are not understood. The study of aerobic scope – the difference between an animal’s baseline and maximal levels of aerobic metabolism – is a promising framework for investigating these costs. Any aerobic capacity directed toward a given oxygen-consuming physiological process results in a reduced ability to perform all others. Immune function, however, has been completely overlooked in this context. Both immune function and aerobic scope can connect environmental factors with behaviour, life-history strategies and ultimately individual fitness, but a direct relationship between the immune system and aerobic scope has never been investigated. This studentship will therefore investigate trade-offs between immune function and other sources of oxygen demand within individual animals.

Fish are a vital component of biodiversity but have been ignored in terms of immunoecological research. This project will therefore lead to a range of further experimental and theoretical studies investigating the role of the immune response in physiological ecology, life-history variation, and responses to environmental change in fish. For instance, several environmental pollutants stimulate the immune response of fish and likely cause a decrease in aerobic scope and probably compromise growth and swimming ability. The interactive effects of temperature increase and hypoxia on immune function and aerobic scope are also critical avenues for future research likely to stem from this project. One potential application is aquaculture where growth maximises profit but the trade-off between the immune response and growth is not understood. Another direction for applications is sports medicine; if intense exercise reduces immune function, understanding the underlying mechanisms would be valuable. Fish are ideal for studying this area because they can be subjected to treatments not possible in humans.

Objectives: This project will address four main questions:
1)How does an immune response affect metabolic rate, aerobic scope, and swimming ability?
2)How does intense exercise affect immune function in relation to aerobic scope in individuals?
3)How are aerobic scope and behavioural personality traits related to immune function?
4)Is there a trade-off between immune function and growth rate within an animal’s aerobic scope?

Training Opportunities: This project integrates aspects of animal physiology, behaviour, ecology, and evolution and therefore provides broad training. In addition, as the examination of fish immunology from an ecophysiological perspective is virtually non-existent to date, this project would provide the student with unique training opportunities and a chance to establish a distinctive niche of research expertise. Specifically, the student will receive training in a number of diverse skills including the measurement of metabolic rate using respirometry, the measurement of locomotor performance, behavioural observation, and techniques associated with measuring immune responses to infection at the cellular level (e.g. flow cytometry, histology). The student will also gain general experience in experimental design and statistical analyses.

Funding Details: NERC standard stipend (£13,590 pa + full fees)

Duration: 3 years (6 month extension available under some circumstances)

Eligibility: The candidate must have been ordinarily resident in the UK throughout the 3-year period preceding the date of application for an award, not wholly or mainly for the purposes of full time education.  Applicants should have received a grade of 2:1 (B) or equivalent in their undergraduate degree; applicants who do not meet this threshold but have completed other postgraduate training programmes might be considered.  More details described here:

How to apply: Full CV + contact details of at least 2 referees.
Cover letter indicating motives and qualifications for undertaking the proposed program
Who to send applications to – Lorna Kennedy ( Е-мейл адресът e защитен от спам ботове. )
Closing Date - January 20, 2011

Please also see details on the College of Medical, Veterinary and Life
Sciences Graduate school website
Note: The Institute of Biodiversity, Animal Health, and Comparative Medicine is advertising four NERC studentships this year in the realistic expectation that two or three of the most competitive applicants will be funded.

Further Information:  To obtain more detailed information about the project, please contact the primary project supervisor, Shaun Killen
( Е-мейл адресът e защитен от спам ботове. ).

Relevant Publications by the Supervisory Team:
1.Killen, S. S., Marras, S., Steffensen, J. F., & McKenzie, D. J. 2011. Aerobic capacity influences the spatial position of individuals within fish schools. Proceedings of the Royal Society B. 279: 357-364.
2.Killen, S. S., Marras, S., Ryan, M. R., Domenici, P, & McKenzie, D. J. 2011. A relationship between metabolic rate and risk-taking behaviour is revealed during hypoxia in juvenile European sea bass. Functional Ecology. doi: 10.1111/j.1365-2435.2011.


3.Killen, S. S., Marras, S., and McKenzie, D. J. 2011. Fuel, fasting, fear: routine metabolic rate and food deprivation exert synergistic effects on risk-taking in individual juvenile European sea bass. Journal of Animal Ecology. 80: 1024–1033.
4.Killen, S. S., Costa, I., Brown, J. A., & Gamperl, A. K. 2007. Little left in the tank: metabolic scaling in marine teleosts and its implications for aerobic scope. Proceedings of the Royal Society B. 274: 431-438.
5.Bize, P., Diaz, C. & Lindström, J. In Press. Experimental evidence that adult antipredator behaviour is heritable and not influenced by behavioural copying in a wild bird. Proceedings of the Royal Society B.
6.Dijkstra, P. D., Lindström, J., Metcalfe, N. B., Hemelrijk, C. K., Brendel, M., Seehausen, O. & Groothuis, T. G. G. 2010: Frequency-dependent social dominance in a color polymorphic cichlid fish. Evolution. 64:2797-2807.
7.Lindström, J., Pike, T. W., Blount, J. D. & Metcalfe, N. B. 2009: Optimization of resource allocation can explain the temporal dynamics and honesty of sexual signals. American Naturalist. 174:515–525.
8.Pike, T. W., Samanta, M., Lindström, J. & Royle, N. J. 2008: Behavioural phenotype affects social interactions in an animal network.  Proceedings of the Royal Society B. 275:2515–2520.
9.Gharbi, K., Glover, K.A., Stone, L.C., MacDonald, E.S., Matthews, L., Grimholt, U. & Stear, M.J. 2009. Genetic dissection of MHC-associated susceptibility to Lepeophtheirus salmonis in Atlantic salmon. BMC Genetics,  10: 1471-2156.
10.Chessa, B., Pereira, F., Arnaud, F., Amorim, A., Goyache, F., Mainland, I., Kao, R.R., Pemberton, J.M, Beraldi, D., Stear, M.J. et. al. 2009. Revealing the history of sheep domestication using retrovirus integrations. Science. 324: 532-536.
11.Bishop, S.C. & Stear, M.J. 2003. Modeling of host genetics and resistance to infectious diseases: understanding and controlling nematode infections. Veterinary Parasitology. 115: 147-166.
12.Strain, S.A.J. & Stear, M.J. 2001. The influence of protein supplementation on the immune response to Haemonchus contortus. Parasite Immunology. 23: 527-531.

Търсене на специалист:

Вход / изход

АКО СТЕ ЗАБРАВИЛИ ПАРОЛАТА: 1. Превключете сайта на английски (най- горе в дясно) 2. Натиснете на "Forgot login?" 3. Попълнете данните 4. След като попълните е-мейла си, дайте ENTER от клавиатурата и след това натиснете SEND 5. Ако не стане - свържете се с нас!

Библиотека статистика

Библиотеката съдържа 253 статии в 37 категории. Понастоящем статиите са свалени общо 78836 пъти.


Кой е на линия

В момента има 38 посетителя в сайта
Hydrobiology Society, Bulgaria >>> Copyright: Lyubomir Kenderov, 2008- 2011 ©